A method for setting parameters in design of a printed circuit board (PCB) includes obtaining multiple combinations of layout parameters of a PCB and inputting the multiple combinations of layout parameters into a predetermined PCB layout simulation software to obtain multiple interference parameter combinations. The multiple combinations of layout parameters and the multiple interference parameter combinations are defined as training samples, and a predetermined network model is trained through the training samples to obtain a first prediction model. The first prediction model is trained and tested to obtain an impedance prediction model. When the multiple combinations of layout parameters are inputted to the impedance prediction model, only an average predetermined error is allowed between impedance values predicted by the impedance prediction model and impedance values calculated by the predetermined PCB layout simulation software, to enable acceptance of that combination.