A medium-high voltage photovoltaic (PV) power generation system is provided. A PV string of the system is insulated from the ground via an insulator of a medium-high voltage withstanding level, so that the PV string is applicable under a high voltage level. The PV strings are connected to cascade modules. An output voltage of series-connected cascade modules is grid-connected to a 10 kV power grid through a three-phase filter, without a power booster transformer or a high-frequency isolated DC/DC converter in a conventional power station, thereby improving the system efficiency.