The disclosed systems and methods are directed to wireless receiver systems for neutralizing the effects of received RF blocking signals. The configurations presented herein operate to receive RF signals containing a desired signal and a blocking signal, a first module, in communication with the receive RF signals along a first signal path and configured to extract a specimen of the received desired and blocking signals, and a second module, in communication with the first module along a second signal path to receive the desired signal and blocking signal specimens. The second module is configured to produce a replica of the blocking signal based on the blocking signal specimen, generate an anti-blocking signal based on the blocking signal replica, and introduce the anti-blocking signal to the received desired and blocking signals in which the anti-blocking signal destructively interferes to neutralize the received blocking signal.