A multi-endpoint adapter device includes a splitter device that is coupled to a network port and a plurality of endpoint subsystems that are each coupled to a processing subsystem. The splitter device receives, via the network port, a first data payload, and identifies both a first data sub-payload that is included in the first data payload and that is associated with a first endpoint subsystem included in the plurality of endpoint subsystems and a second data sub-payload that is included in the first data payload and that is associated with a second endpoint subsystem included in the plurality of endpoint subsystems. The splitter device then splits the first data payload into the first data sub-payload and the second data sub-payload, and forwards both the first data sub-payload to the first endpoint subsystem and the second data sub-payload to the second endpoint subsystem.