Systems for managing dynamic configuration-based database connections using a proxy datasource are disclosed. In embodiments, a computer program product is provided including a computer readable storage medium having program instructions embodied therewith. The program instructions are executable by a computing device to cause the computing device to: send, by a software application of the computing device, a request for a connection to a first database to a proxy datasource of the computing device, wherein the request includes a database identifier and configuration data; pass, by a first concrete datasource of the computing device, a connection to the first database to the proxy datasource; return, by the proxy datasource of the computing device, the connection to the software application; and access, by the software application of the computing device, the first database via the connection.