A liquid dispensing system for oral administration comprises a dispenser (16,18,20) and cartridges (14) from which medicine is dispensed. Each cartridge (14) includes a hollow shell (22,24) with a septum (26) at one end, a piston (28) at the other end, and the medicine in a cavity (23) between the septum and the piston. The dispenser includes receiver (20) in which a cartridge (14) is received, a plunger (18) that can slide relative to the receiver and that has a plunging head (52) that can drive the piston (28), and a barrel (16) in which the cartridge (14), receiver (20) and plunger (18) can be received, at least partly. Once a cartridge (14) has been inserted into the receiver (20), the receiver and cartridge are inserted into the barrel (16) and a piercing head (44) ruptures the septum (26). The plunger (18) is pushed to drive the piston (28) and the medicine is dispensed by the piston, through a discharge passage (42) of the barrel (16). The septum (26) can hinge on a hinge formation (86) to act as a one-way valve to prevent unintentional flow of liquid from the cartridge.