Invention Grant
- Patent Title: Microsphere-based delivery and ex vivo manipulation of dendritic cells for autoimmune therapies
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Application No.: US16297484Application Date: 2019-03-08
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Publication No.: US10940164B2Publication Date: 2021-03-09
- Inventor: Nick Giannoukakis , Massimo M. Trucco
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K35/15
- IPC: A61K35/15 ; C12N5/0784 ; A61K9/00 ; C12N15/113
Abstract:
The present invention relates to tolerogenic mammalian dendritic cells (iDCs) and methods for the production of tolerogenic DCs. In addition, the present invention provides methods for administration of tolerogenic dendritic cells as well as particles containing oligonucleotides to mammalian subjects. Enhanced tolerogenicity in a host can be useful for treating inflammatory and autoimmune related diseases, such as type 1 diabetes.
Public/Granted literature
- US20190321398A1 MICROSPHERE-BASED DELIVERY AND EX VIVO MANIPULATION OF DENDRITIC CELLS FOR AUTOIMMUNE THERAPIES Public/Granted day:2019-10-24
Information query
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