The present invention relates to a pharmaceutical combination for inducing one or more immune responses and/or for enhancing effectiveness of vaccination in the host, which is capable of inducing cross-protection against multiples strains and/or serotypes of a virus. In one embodiment, the pharmaceutical combination is able to generate protection in food producing animals, such as cattle, sheep, goats, swine and other cloven-hoofed animals with fewer vaccination campaigns. This universal vaccine comprises an inactivated virus with one or more of the following components: polynucleotides encoding viral peptides, polypeptides or proteins in different types of plasmids; viral peptides, polypeptides and proteins; synthetic viral peptides and polypeptides; recombinant viral peptides, polypeptides and proteins; virus-like-particles; virus-like-particles derived from other viruses; proteins used as a carrier or as molecular adjuvant fused to peptides, polypeptides and/or proteins derived from viruses; adjuvants; emulsifiers, molecular adjuvants and carrier systems.