Invention Grant
- Patent Title: Ice-based lipid nanoparticle formulation for delivery of mRNA
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Application No.: US16773638Application Date: 2020-01-27
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Publication No.: US10940207B2Publication Date: 2021-03-09
- Inventor: Frank DeRosa , Michael Heartlein , Shrirang Karve
- Applicant: Translate Bio, Inc.
- Applicant Address: US MA Lexington
- Assignee: Translate Bio, Inc.
- Current Assignee: Translate Bio, Inc.
- Current Assignee Address: US MA Lexington
- Agency: Proskauer Rose LLP
- Agent Fangli Chen; Sang-Ah Kim
- Main IPC: A61K47/54
- IPC: A61K47/54 ; A61K38/17 ; A61K47/28 ; A61K47/60 ; A61K47/69 ; A61K48/00 ; A61K9/00 ; A61K9/127 ; A61P11/12
Abstract:
The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid. In some embodiments, the present invention provides compositions and methods in which the lipid nanoparticles further comprise helper lipids and PEG-modified lipids. The resulting formulation comprises a high encapsulation percentage for nucleic acids.
Public/Granted literature
- US20200155691A1 ICE-BASED LIPID NANOPARTICLE FORMULATION FOR DELIVERY OF MRNA Public/Granted day:2020-05-21
Information query
