Invention Grant
- Patent Title: Adipocyte-targeting non-viral gene delivery complex comprising dual plasmid vector
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Application No.: US16315346Application Date: 2017-06-30
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Publication No.: US10940215B2Publication Date: 2021-03-09
- Inventor: Yong-Hee Kim , Hyung Jin Kim , Jee Young Chung , Yoon Sung Song
- Applicant: Industry-University Cooperation Foundation Hanyang University
- Applicant Address: KR Seoul
- Assignee: Industry-University Cooperation Foundation Hanyang University
- Current Assignee: Industry-University Cooperation Foundation Hanyang University
- Current Assignee Address: KR Seoul
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2016-0084631 20160705
- International Application: PCT/KR2017/006963 WO 20170630
- International Announcement: WO2018/008903 WO 20180111
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/04 ; A61P3/04 ; C12N15/113 ; C12N15/85

Abstract:
The present disclosure relates to: an adipocyte-targeting non-viral gene delivery complex comprising a sh(FABP4+FABP5) dual plasmid vector; and treatment for obesity and obesity-induced metabolic syndromes by using the same and, more particularly, to a gene delivery complex comprising: an adipocyte-targeting sequence; a nine-arginine (R9) peptide; and a dual plasmid vector comprising a gene for treatment of obesity and obesity-induced metabolic syndromes, wherein the gene for treatment of obesity and obesity-induced metabolic syndromes is a base sequence inhibiting the expression of a FABP4 gene and a FABP5 gene. According to the present disclosure, in order to treat obesity-related diseases, a dual plasmid vector capable of simultaneously inhibiting the FABP4 and FABP5 genes is produced, and this vector is bound to a predetermined delivery system that specifically delivers the vector into adipocytes so as to provide a gene delivery complex. In this way, it is possible to achieve an excellent therapeutic effect on obesity which targets only adipocytes without cytotoxicity.
Public/Granted literature
- US20190307898A1 ADIPOCYTE-TARGETING NON-VIRAL GENE DELIVERY COMPLEX COMPRISING DUAL PLASMID VECTOR Public/Granted day:2019-10-10
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