Mixing systems and methods include a mixing device comprising a primary tube having a proximal end, a distal end, an outer surface and an inner lumen and at least one secondary tube having a proximal end, a distal end, an outer surface and an inner lumen. The at least one secondary tube is substantially parallel to the primary tube. The distal end of the at least one secondary tube is fluidly connected to the primary tube at a junction located on the primary tube close to the distal end of the primary tube.