An ultrasound stimulation helmet (100) configured to regulate an endogenous neurotrophic factor in a brain or expression of proteins related to a neurodegenerative disease comprises: a main body (1) having a forehead perimeter adjustment knob (12), a back head perimeter adjustment knob (13), a fastening support frame (14), and multiple position adjustment knobs (15); and multiple ultrasound probes (2) detachably mounted on the main body (1), wherein the ultrasound probe (2) has a frequency adjustment button and an intensity adjustment button to respectively control an output frequency and output intensity of the ultrasound probe (2), and other ultrasound parameters and an angle of the ultrasound probe (2) itself are adjustable as well. The fastening support frame (14) can be used to adjust the length of the main body (1) according to the size of a head of a patient, and the ultrasound probes (2) are connected to the position adjustment knobs (15) to enable the ultrasound probes (2) to move upward, downward, or toward the left or right with respect to the head of the patient.