A method of operating a vehicle having a hybrid drive, a transmission with shift elements, a drive output with a brake, a main transmission with input shafts, an output shaft and planetary gear sets (PG1, PG2). The main transmission has five gear planes. One shift element can connect a gear plane to an element of gear set (PG1) adjoining the main transmission. Another shift element couples a further element of gear set (PG1) either to the output shaft or a housing. An electric machine is permanently connected to an element of gear set (PG2). If, while driving with a transmission gear engaged, the drive output brake is engaged for a full brake application, a shift element of the transmission is first relieved by the electric machine and/or a brake assigned to one of the input shafts and then subsequently disengaged to decouple the combustion engine from the drive output.