Invention Grant
![5-[(piperazin-l-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis](/docs/US/2021-03-09/US10941117B2/abs.jpg.600x600.jpg)
- Patent Title: 5-[(piperazin-l-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis
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Application No.: US16653668Application Date: 2019-10-15
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Publication No.: US10941117B2Publication Date: 2021-03-09
- Inventor: Franck Laurent Brebion , Luke Jonathan Alvey , David Amantini , Frédéric André De Ceuninck , Pierre Marc Marie Joseph Deprez , Romain Luc Marie Gosmini , Hélène Marie Jary , Christophe Peixoto , Iuliana Ecaterina Pop-Botez , Marie Laurence Claire Varin
- Applicant: GALAPAGOS NV , LES LABORATOIRES SERVIER
- Applicant Address: BE Mechelen; FR Suresnes
- Assignee: GALAPAGOS NV,LES LABORATOIRES SERVIER
- Current Assignee: GALAPAGOS NV,LES LABORATOIRES SERVIER
- Current Assignee Address: BE Mechelen; FR Suresnes
- Agency: Arent Fox LLP
- Priority: EP14307129 20141222
- Main IPC: C07D233/78
- IPC: C07D233/78 ; A61P19/04 ; A61P19/02 ; A61K31/55 ; C07D417/12 ; C07D405/12 ; C07D401/14 ; C07D401/12 ; C07D401/04 ; A61K31/5377 ; A61K31/496 ; C07D403/06 ; C07D403/14
![5-[(piperazin-l-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis](/abs-image/US/2021/03/09/US10941117B2/abs.jpg.150x150.jpg)
Abstract:
The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein.
The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.
The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.
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