Invention Grant
- Patent Title: Anti-TrkB agonist antibodies binding to D5 domain of TrkB and methods of promoting neuronal survival in motor neuron injury, stroke or glaucoma
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Application No.: US16492954Application Date: 2018-03-15
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Publication No.: US10941203B2Publication Date: 2021-03-09
- Inventor: Bai Lu , Wei Guo , Hongyang Yao
- Applicant: TSINGHUA UNIVERSITY
- Applicant Address: CN Beijing
- Assignee: TSINGHUA UNIVERSITY
- Current Assignee: TSINGHUA UNIVERSITY
- Current Assignee Address: CN Beijing
- Agency: Jun He Law Offices P.C.
- Agent James J. Zhu
- Priority: WOPCT/CN2017/076728 20170315
- International Application: PCT/CN2018/079109 WO 20180315
- International Announcement: WO2018/166495 WO 20180920
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/00 ; C12P21/08 ; G01N33/53 ; A61K49/00 ; A61K49/16 ; C07K14/00 ; A61K38/00 ; C07K16/28 ; A61P25/28 ; A61K38/18 ; A61P25/00 ; A61P25/02 ; A61P27/00 ; A61P27/06 ; A61P27/02 ; C07K16/00 ; C07K14/48 ; A61P9/10 ; C07K16/18 ; A61P25/14 ; A61K9/00 ; A61K38/17 ; C07K14/705 ; C07K14/47 ; A61P25/16 ; C12N5/0793 ; A61P21/00 ; A61L27/38
Abstract:
Provided is an isolated TrkB agonist antibody that binds to an epitope contained in one of the extracellular domains of TrkB and is capable of activating TrkB, wherein the extracellular domains comprises extracellular D1, D2, D3, D4, D5 domains and juxtamembrane domain of TrkB. Methods of using the TrkB agonist antibody in treating or reducing the risk of a TrkB associated conditions in a subject, wherein said condition is selected from cell differentiation, synaptic development, neural injury repairing and/or neurite branching.
Public/Granted literature
- US20200017590A1 NOVEL ANTI-TRKB ANTIBODIES Public/Granted day:2020-01-16
Information query
