Invention Grant
- Patent Title: Sequencing methods and compositions for prenatal diagnoses
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Application No.: US15601951Application Date: 2017-05-22
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Publication No.: US10941442B2Publication Date: 2021-03-09
- Inventor: Richard P. Rava , Manjula Chinnappa , David A. Comstock , Gabrielle Heilek , Brian Kent Rhees
- Applicant: Verinata Health, Inc.
- Applicant Address: US CA Redwood City
- Assignee: Verinata Health, Inc.
- Current Assignee: Verinata Health, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Mueting Raasch Group
- Main IPC: C12Q1/6869
- IPC: C12Q1/6869 ; C12Q1/6806 ; C12Q1/6809 ; G16B30/10 ; G16H10/40 ; C12Q1/6883
Abstract:
The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.
Public/Granted literature
- US20170327881A1 SEQUENCING METHODS AND COMPOSITIONS FOR PRENATAL DIAGNOSES Public/Granted day:2017-11-16
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