An electronic ink display screen, wherein a spacer frame is coated on the pixel electrode by a One Drop Filling (ODF) process, the spacer frame includes a first spacer frame and a second spacer frame. The second spacer frame is located on a side of the first spacer frame. The electronic ink microcapsule array is provided inside the first spacer frame. Conductive silver paste is provided inside the second spacer frame. The upper transparent electrode is covered on the spacer frame. The conductive silver paste electrically contacts the pixel electrode and the upper transparent electrode, respectively. Peripheries of the spacer frame and the upper transparent electrode are sealed and fixed by a waterproof adhesive. The electronic ink display screen of the present invention uses the ODF production process, so there is no complicated process in the production of the traditional electronic paper film sheet.