A system and method of detecting medical fraud using blockchains including receiving a prescription comprising first prescription data from a prescription entry device associated with an prescribing entity, generating a validation code for the prescription based on the first prescription data, adding the validation code to the first prescription data, appending the first prescription data including the validation code to a blockchain, and receiving a query associated with the prescription from a prescription verification device associated with a prescription dispensing entity. The query includes second prescription data. The method further includes comparing the first prescription data to the second prescription data, for example, using pixel comparison, determining based on the comparison that the prescription has been modified, and transmitting to the prescription verification device an indication that the prescription has been modified.