Technologies are described for delivering an active agent using an ingestible pill device, securing medication package content, and monitoring the medication package content. Examples of the technology include using an ingestible pill device to deliver an active agent, where release of the active agent can be based on patient authentication, analyzing sensor data to determine a condition for releasing the active agent, analyzing image data to identify a release point, etc. Examples of the technology also include using a monitoring device to secure a medication package using a cover and locking device, monitoring the medication package to detect access to the medication package, and tracking access to the medication package to determine medication adherence.