The present disclosure relates to an driving method of an active matrix organic light-emitting diode (AMOLED) display panel, including: calculating a first proportion group and a second proportion group corresponding to each of color channels in display images of the AMOLED display panel at the first moment and the second moment, determining whether the first proportion group and the second proportion group are the same, calculating a theoretical current value corresponding to a target color channel to maintain a predetermined display brightness, obtaining an actual current value transmitted by the current detector, comparing the actual current value with the theoretical current value by the comparator, obtaining a target driving voltage value corresponding to a target proportion in the second proportion group when the actual current value is greater than the theoretical current value, adjusting a driving voltage provided by the PMIC power supply to the target drive voltage.