Invention Grant
- Patent Title: Crystalline form of triethylenetetramine tetrahydrochloride and its pharmaceutical use
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Application No.: US16917266Application Date: 2020-06-30
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Publication No.: US10947184B2Publication Date: 2021-03-16
- Inventor: Timothy James Morley , Ronnie Maxwell Lawrence , Naseem Amin
- Applicant: ORPHALAN S.A.
- Applicant Address: FR Paris
- Assignee: ORPHALAN S.A.
- Current Assignee: ORPHALAN S.A.
- Current Assignee Address: FR Paris
- Agency: Klarquist Sparkman, LLP
- Priority: EP8290048 20180504
- Main IPC: C07C211/14
- IPC: C07C211/14 ; C07C209/84 ; A61K9/00
Abstract:
The present invention describes a new crystalline form of triethylenetetramine tetrachloride which has improved room temperature stability over known forms and over the dichloride salt. The new crystalline form is characterised by having peaks in an XRPD spectrum at 22.9, 25.4, 25.8, 26.6, 34.6 and 35.3±0.1°2θ and Raman shifts 943, 1173, 1527 and 1612±5 cm−1. The crystalline form of triethylenetetramine tetrachloride is useful in the treatment of Wilson's disease.
Public/Granted literature
- US10988436B2 Crystalline form of triethylenetetramine tetrahydrochloride and its pharmaceutical use Public/Granted day:2021-04-27
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