Invention Grant
- Patent Title: Small molecule ferroptosis inducers
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Application No.: US16445104Application Date: 2019-06-18
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Publication No.: US10947188B2Publication Date: 2021-03-16
- Inventor: Brent R. Stockwell , Kenichi Shimada , Rachid Skouta
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Bryan Cave Leighton Paisner LLP
- Main IPC: C07C311/15
- IPC: C07C311/15 ; C07D401/12 ; C07D407/12
Abstract:
The present invention provides, inter alia, a compound according to formula (I): Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for regulating GPX4 in a cell and methods for inducing ferroptosis in a cell.
Public/Granted literature
- US20190315681A1 SMALL MOLECULE FERROPTOSIS INDUCERS Public/Granted day:2019-10-17
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