Invention Grant
- Patent Title: Spiro and cyclic bis-benzylidene proteasome inhibitor for the treatment of cancer, diabetes and neurological disorders
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Application No.: US16481562Application Date: 2018-01-30
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Publication No.: US10947199B2Publication Date: 2021-03-16
- Inventor: Yung-Nien Chang
- Applicant: UP THERAPEUTICS, INC.
- Applicant Address: US MD Elkridge
- Assignee: UP THERAPEUTICS, INC.
- Current Assignee: UP THERAPEUTICS, INC.
- Current Assignee Address: US MD Elkridge
- Agency: Cermak Nakajima & McGowan LLP
- Agent Malcolm K. McGowan
- International Application: PCT/US2018/015826 WO 20180130
- International Announcement: WO2018/140907 WO 20180802
- Main IPC: C07D221/20
- IPC: C07D221/20 ; A61K31/397 ; A61K31/403 ; A61K31/438 ; C07D205/12 ; C07D209/54
Abstract:
Described herein are spiro and cyclic bis-benzylidine proteasome inhibitors, which inhibit the proteasome function through either ubiquitin receptor ADRM1/RPN13 or proteasome DUB enzymes (USP14, UCH37 and RPN11), and which can be used for the treatment of cancers/diabetes/neurological disorders.
Information query
