Invention Grant
- Patent Title: 4β-amidotriazole linked podophyllotoxin derivatives as potential anticancer agents
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Application No.: US16084162Application Date: 2017-03-10
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Publication No.: US10947248B2Publication Date: 2021-03-16
- Inventor: Ahmed Kamal , Velma Ganga Reddy , Ayinampudi Venkata Subbarao , Syed Riyaz , Vadithe Lakshma Nayak , Shaik Taj
- Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Applicant Address: IN New Delhi
- Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Current Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Current Assignee Address: IN New Delhi
- Agency: Norton Rose Fulbright US LLP
- Priority: IN201611008486 20160311
- International Application: PCT/IN2017/050088 WO 20170310
- International Announcement: WO2017/154026 WO 20170914
- Main IPC: C07D493/04
- IPC: C07D493/04 ; A61P35/00 ; A61P31/12
Abstract:
The present invention relates to a compound of general formula (A). The invention provides asynthesis of new 4β-amidotriazole linked podophyllotoxin derivatives of general formulae 8a-z to 9a-z useful as potential anticancer agents against human cancer cell lines and process for the preparation thereof. Wherein n=0, 1 and R1-R5═[H, CI, F, CH3, OCH3, 3,4(-OCH2O—), CF3, OCF3, m-OC6H5, OH]
Information query
