Invention Grant
- Patent Title: Caged cell penetrating peptide-polymer conjugates for diagnostic and therapeutic applications
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Application No.: US16205275Application Date: 2018-11-30
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Publication No.: US10947275B2Publication Date: 2021-03-16
- Inventor: Ayelet David , Gonen Ashkenasy , Yosi Shamay
- Applicant: Ben-Gurion University of the Negev Research and Development Authority
- Applicant Address: IL Beer Sheva
- Assignee: Ben-Gurion University of the Negev Research and Development Authority
- Current Assignee: Ben-Gurion University of the Negev Research and Development Authority
- Current Assignee Address: IL Beer Sheva
- Agency: Cooley LLP
- Agent Ivor R. Elrifi; Matthew Pavao
- Main IPC: A61K49/14
- IPC: A61K49/14 ; A61K51/00 ; A61K51/08 ; A61K49/00 ; C07K9/00 ; A61K47/64 ; A61K47/32
Abstract:
The caged cell-penetrating peptide (cCPP) conjugates of this invention are ideal for intracellular delivery of a broad variety of cargoes including various nanoparticle pharmaceutical carriers (liposomes, micelles, microparticles, nanoparticles, polymer-conjugates). The conjugates comprise a detectable agent or a therapeutic agent, and the conjugates provide a novel strategy for site-specific delivery of the same to appropriate tissues in the subject. Versatile application of the conjugates in diagnostics and imaging is described.
Public/Granted literature
- US20190225653A1 CAGED CELL PENETRATING PEPTIDE-POLYMER CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS Public/Granted day:2019-07-25
Information query
