A ladder stabilization system for holding a ladder in place on a support surface that can include a pair of opposed ladder stabilizer devices that are configured to be operatively placed in opposition to receive a bottom portion of the pair of spaced legs of the ladder to positionally fix the ladder relative to the vertical structure. The ladder stabilization system acts to secure and stabilize the bottom portion of the ladder to prevent the base of the ladder from sliding, skidding, or otherwise moving while a user is on the ladder. The present invention improves user safety and reduces the need for having a second individual support the base of the ladder.