A color filter substrate, a manufacturing method thereof, and a corresponding display panel. The manufacturing method of the color filter substrate includes: providing a substrate; forming an array of a plurality of pixel units on the substrate, wherein each pixel unit comprises a first sub-pixel, a second sub-pixel and at least two third sub-pixels, the at least two third sub-pixels being made of an irreversible temperature-sensitive pigment; and performing a temperature-variation treatment on one third sub-pixel in each pixel unit such that the one third sub-pixel changes color and becomes a fourth sub-pixel.