A signal transceiver device includes a transceiver circuit, a switching circuit, a compensation circuit, and a calibration circuit. The transceiver circuit includes a transmitter and a receiver. The switching circuit has a first configuration and a second configuration, in which the transmitter is coupled to the receiver via the switching circuit. The compensation circuit analyzes an output of the receiver to obtain a first analyzed result and a second analyzed result, and generates first compensation coefficients and second compensation coefficients, in which the first analyzed result is corresponding to the first configuration, and the second analyzed result is corresponding to the second configuration. The calibration circuit calibrates the transmitter according to the first compensation coefficients, and calibrates the receiver according to the second compensation coefficients.