- Patent Title: Benzothiophene compound, alternative autophagy-inducing agent and anticancer agent including the compound as active ingredient, and method for screening for compound having anticancer activity
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Application No.: US14376671Application Date: 2013-02-07
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Publication No.: US10954222B2Publication Date: 2021-03-23
- Inventor: Shigeomi Shimizu , Takamitsu Hosoya , Michiko Murohashi , Suguru Yoshida
- Applicant: National University Corporation Tokyo Medical and Dental University
- Applicant Address: JP Tokyo
- Assignee: National University Corporation Tokyo Medical and Dental University
- Current Assignee: National University Corporation Tokyo Medical and Dental University
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: JPJP2012-026373 20120209,JPJP2012-026377 20120209
- International Application: PCT/JP2013/052947 WO 20130207
- International Announcement: WO2013/118842 WO 20130815
- Main IPC: A61K49/00
- IPC: A61K49/00 ; C07D409/04 ; C07D333/68 ; G01N33/50 ; A61K31/381
Abstract:
It has been found that efficient screening for a compound having anticancer activity can be achieved by selecting a compound having activity to induce alternative autophagy using, as an index, formation of fluorescent bright spots due to aggregation of a lysosomal protein to which a fluorescent protein is attached in cells expressing the lysosomal protein. In addition, it has been found that a benzothiophene compound represented by the following general formula (1) has alternative autophagy-inducing activity and anticancer activity:
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