Invention Grant
- Patent Title: Method for purifying ropinirole hydrochloride
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Application No.: US16623085Application Date: 2017-06-16
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Publication No.: US10961194B2Publication Date: 2021-03-30
- Inventor: Guoliang Tu , Zhongming Xu , Tao Zhou , Wenfeng Huang , Shiwen Zhang
- Applicant: Zhejiang Huahai LiCheng Pharmaceutical Co., Ltd. , Zhejiang Huahai Pharmaceutical Co., Ltd.
- Applicant Address: CN Taizhou; CN Taizhou
- Assignee: Zhejiang Huahai LiCheng Pharmaceutical Co., Ltd.,Zhejiang Huahai Pharmaceutical Co., Ltd.
- Current Assignee: Zhejiang Huahai LiCheng Pharmaceutical Co., Ltd.,Zhejiang Huahai Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Taizhou; CN Taizhou
- Agency: Blank Rome LLP
- International Application: PCT/CN2017/088651 WO 20170616
- International Announcement: WO2018/227553 WO 20181220
- Main IPC: C07D209/34
- IPC: C07D209/34

Abstract:
Provided is a method for purifying ropinirole hydrochloride (4-2-di-n-propylaminoethyl-1,3-dihydro-2H-indole-2-ketohydrochloride). The method comprises: adding ropinirole hydrochloride containing a monopropyl impurity A into water, adding organic solvent, stirring and dissolving at room temperature, adding alkali, stirring, standing, demixing, and removing an aqueous layer; optionally, drying the organic layer by using anhydrous magnesium sulfate, and filtering; and adding acyl chloride or acid anhydride into the organic layer, stirring, concentrating the organic layer to be dry, adding an organic solvent into the obtained oily matter, adding concentrated hydrochloric acid, and stirring, so as to obtain the ropinirole hydrochloride. By using the method, the impurity A in the ropinirole hydrochloride can be effectively removed, and the ropinirole hydrochloride can be obtained with a high yield and a high purity, so that the impurity A is controlled and the purity of the product reaches a medicinal standard.
Public/Granted literature
- US20200172482A1 METHOD FOR PURIFYING ROPINIROLE HYDROCHLORIDE Public/Granted day:2020-06-04
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