Invention Grant
- Patent Title: Small molecule modulators of the androgen receptor
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Application No.: US16198553Application Date: 2018-11-21
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Publication No.: US10961216B2Publication Date: 2021-03-30
- Inventor: David Freeman , Nicholas B. Struntz , Shelby K. Doyle , Andre Richters , Angela N. Koehler
- Applicant: Massachusetts Institute of Technology
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology
- Current Assignee: Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D495/04 ; C07D211/46 ; A61P35/00 ; A61K31/519 ; A61K31/445 ; A61K31/4545 ; A61K45/06 ; A61K31/55 ; C07D401/12
Abstract:
Provided herein are compounds useful for modulating the activity of an androgen receptor, or a variant thereof, and related compositions and methods. Compounds of the invention are useful for antagonizing the androgen receptor splice variant AR-v7, and for the treatment of castration-resistant prostate cancer.
Public/Granted literature
- US20190202800A1 SMALL MOLECULE MODULATORS OF THE ANDROGEN RECEPTOR Public/Granted day:2019-07-04
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