Invention Grant
- Patent Title: Bridged nucleic acid GuNA, method for producing same, and intermediate compound
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Application No.: US15760513Application Date: 2016-09-20
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Publication No.: US10961269B2Publication Date: 2021-03-30
- Inventor: Satoshi Obika , Eiji Kawanishi , Hiroaki Sawamoto , Shuhei Yamakoshi , Yuuki Aral , Shinji Kumagai
- Applicant: MITSUBISHI TANABE PHARMA CORPORATION , OSAKA UNIVERSITY
- Applicant Address: JP Osaka; JP Suita
- Assignee: MITSUBISHI TANABE PHARMA CORPORATION,OSAKA UNIVERSITY
- Current Assignee: MITSUBISHI TANABE PHARMA CORPORATION,OSAKA UNIVERSITY
- Current Assignee Address: JP Osaka; JP Suita
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JPJP2015-185730 20150918,JPJP2016-039351 20160301
- International Application: PCT/JP2016/077748 WO 20160920
- International Announcement: WO2017/047816 WO 20170323
- Main IPC: C07H19/06
- IPC: C07H19/06 ; C07H9/06 ; C07H21/00 ; C07H19/16 ; C07H1/00 ; C07C279/16 ; C07D498/04 ; C07D498/08
Abstract:
A method for preparing a compound represented by general formula I: or a salt thereof includes a step of reacting a compound represented by formula II: with a reducing agent to cleave an oxazolidine ring fused to a cycle A′. The reducing agent includes at least one of phosphines, metal hydrides, or transition metal catalysts in the presence of hydrogen gas.
Public/Granted literature
- US20180251488A1 CROSSLINKED NUCLEIC ACID GUNA, METHOD FOR PRODUCING SAME, AND INTERMEDIATE COMPOUND Public/Granted day:2018-09-06
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