Invention Grant
- Patent Title: Polymerase variants
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Application No.: US16802426Application Date: 2020-02-26
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Publication No.: US10961520B2Publication Date: 2021-03-30
- Inventor: Aruna Ayer , Cleoma Renetta Arnold , Arkadiusz Bibillo , Mara Boenitz-Dulat , Barbara Eckert , Ilya Lederman , Colin Alexander McGaw , Charles Wayan Schwab , Tyler O'Brien Shultz , Shawn Suko , Eileen Thai , Bigna Woersdoerfer , David Daniel Wunderlich
- Applicant: Roche Molecular Systems, Inc. , Roche Sequencing Solutions, Inc.
- Applicant Address: US CA Pleasanton; US CA Pleasanton
- Assignee: Roche Molecular Systems, Inc.,Roche Sequencing Solutions, Inc.
- Current Assignee: Roche Molecular Systems, Inc.,Roche Sequencing Solutions, Inc.
- Current Assignee Address: US CA Pleasanton; US CA Pleasanton
- Agency: Roche Molecular Systems, Inc.
- Main IPC: C12N9/12
- IPC: C12N9/12
Abstract:
Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363, S365Q, S366, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 and combinations thereof.
Information query
