Invention Grant
- Patent Title: Hyperactive AID/APOBEC and hmC dominant TET enzymes
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Application No.: US16025261Application Date: 2018-07-02
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Publication No.: US10961525B2Publication Date: 2021-03-30
- Inventor: Rahul M. Kohli , Emily Schutsky , Monica Yun Liu
- Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Applicant Address: US PA Philadelphia
- Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee Address: US PA Philadelphia
- Agency: Howson & Howson LLP
- Agent Kathleen D. Rigaut
- Main IPC: C12N9/78
- IPC: C12N9/78 ; C12N9/02
Abstract:
The present invention includes mutant AID, APOBEC, and Tet enzymes with improved functions. In one aspect the invention provides APOBEC fusion proteins comprising hyperactive deamination activity. In another aspect, the invention provides AID mutant proteins comprising hyperactive deamination activity. In yet another aspect, the invention provides mutant Tet proteins capable of stalling oxidation at a 5-hydroxymethylcytosine (hmC).
Public/Granted literature
- US20190010478A1 Hyperactive AID/APOBEC and hmC Dominant TET Enzymes Public/Granted day:2019-01-10
Information query
