Invention Grant
- Patent Title: Purification, extraction and analyses of fetal neurally-derived exosomes in maternal blood and neonatal neurally-derived exosomes from neonatal blood
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Application No.: US16068738Application Date: 2017-01-06
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Publication No.: US10962555B2Publication Date: 2021-03-30
- Inventor: Laura Goetzl , Edward Goetzl
- Applicant: Temple University—Of The Commonwealth System of Higher Education
- Applicant Address: US PA Philadelphia
- Assignee: Temple University—Of The Commonwealth System of Higher Education
- Current Assignee: Temple University—Of The Commonwealth System of Higher Education
- Current Assignee Address: US PA Philadelphia
- Agency: Riverside Law LLP
- International Application: PCT/US2017/012478 WO 20170106
- International Announcement: WO2017/120436 WO 20170713
- Main IPC: G01N33/68
- IPC: G01N33/68 ; C12Q1/6883

Abstract:
The present invention provides for the first time the identification of fetal neural exosomal biomarkers isolated from maternal plasma useful in diagnosing fetal neurodevelopmental outcomes. The invention also provides the identification of neonatal neural exosomal biomarkers isolated from neonatal plasma useful in diagnosing neonatal neurodevelopmental outcomes The present invention therefore provides methods, kits and systems for diagnosing fetal neurodevelopmental outcomes, by examining relevant proteins and RNA in fetal neural exosomes isolated from a maternal plasma and neonatal neural exosomes isolated from neonatal plasma.
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