Active Noise Cancellation (ANC) systems and methods that reduce latency to improve performance. In certain embodiments the systems sample a noise signal using a sample period to create a stream of digital signal data that is representative of the noise signal. A data transport layer carries the digital signal data to a signal processor. The transport layer temporally organizes the digital signal data to place the digital signal data within an initial phase of a sample period. The remaining phase of the sample period is set to a duration that allows the signal processor to process the digital signal data carried in the initial phase and to output the processed data during the same sample period. In this way, the processing of data occurs within one sample period and the latency is reduced and predictable.