Invention Grant
- Patent Title: USP30 inhibitors
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Application No.: US16606817Application Date: 2018-05-14
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Publication No.: US10968172B2Publication Date: 2021-04-06
- Inventor: Arthur Kluge , Bharat Lagu , Pranab Maiti , Sunil Kumar Panigrahi
- Applicant: Mitobridge, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Mitobridge, Inc.
- Current Assignee: Mitobridge, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Wei Song
- International Application: PCT/US2018/032486 WO 20180514
- International Announcement: WO2018/213150 WO 20181122
- Main IPC: C07C311/16
- IPC: C07C311/16 ; C07D333/38 ; C07D309/08 ; C07D213/81 ; C07D233/96 ; C07D277/56 ; C07D307/24 ; C07D333/24 ; C07D237/24 ; C07D213/56 ; C07D263/34 ; C07D309/06 ; C07D233/64
Abstract:
The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mitochondrial defects including neurodegenerative diseases such as Alzheimer's and Parkinson's or a neoplastic disease such as leukemia.
Information query
