Invention Grant
- Patent Title: Substituted β-lapachones for treating cancer
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Application No.: US16599339Application Date: 2019-10-11
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Publication No.: US10968196B2Publication Date: 2021-04-06
- Inventor: Peter Wipf , Chaemin Lim , Wei Qian , Bennett Van Houten
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: The Webb Law Firm
- Main IPC: A61K31/352
- IPC: A61K31/352 ; C07D311/92 ; A61K45/06 ; A61P25/28 ; A61P35/00 ; C07D405/12
Abstract:
Compounds are provided that are useful in treating cancer and neurodegeneration. The compounds comprise a β-lapachone or β-lapachone derivative tricyclic ortho-naphthoguinone moiety linked to a mitochondria-targeting moiety, for example as defined with respect to Formula (I): or a pharmaceutically-acceptable salt thereof. Pharmaceutical compositions are provided comprising the composition. Methods of treatment of cancer and neurodegenerative disorders also are provided.
Public/Granted literature
- US20200095220A1 Substituted Beta-Lapachones and Uses Therefor Public/Granted day:2020-03-26
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