Invention Grant
- Patent Title: Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels
-
Application No.: US16345913Application Date: 2017-11-13
-
Publication No.: US10968210B2Publication Date: 2021-04-06
- Inventor: Thomas J. Greshock , James Mulhearn , Anthony J. Roecker , Tianying Jian , Gang Zhou , Liangqin Guo , Walter Won , Ting Zhang , Rajan Anand , John E. Stelmach , Deping Wang , Ronald M. Kim , Mark E. Layton , Christopher S. Burgey , Philippe G. Nantermet
- Applicant: Merck Sharp & Dohme Corp. , Thomas J. Greshock , James Mulhearn , Anthony J. Roecker , Tianying Jian , Gang Zhou , Liangqin Guo , Walter Won , Ting Zhang , Rajan Anand , John E. Stelmach , Deping Wang , Ronald M. Kim , Mark E. Layton , Christopher S. Burgey , Philippe G. Nantermet
- Applicant Address: US NJ Rahway; US PA Collegeville; US PA North Wales; US PA West Point; US NJ Westfield; US NJ Bridgewater; US NJ Edison; US CA San Carlos; US NJ Princeton Junction; US NJ Fanwood; US NJ Westfield; US PA Furlong; US NJ Summit; US PA Harleysville; US PA Philadelphia; US PA North Wales
- Assignee: Merck Sharp & Dohme Corp.,Thomas J. Greshock,James Mulhearn,Anthony J. Roecker,Tianying Jian,Gang Zhou,Liangqin Guo,Walter Won,Ting Zhang,Rajan Anand,John E. Stelmach,Deping Wang,Ronald M. Kim,Mark E. Layton,Christopher S. Burgey,Philippe G. Nantermet
- Current Assignee: Merck Sharp & Dohme Corp.,Thomas J. Greshock,James Mulhearn,Anthony J. Roecker,Tianying Jian,Gang Zhou,Liangqin Guo,Walter Won,Ting Zhang,Rajan Anand,John E. Stelmach,Deping Wang,Ronald M. Kim,Mark E. Layton,Christopher S. Burgey,Philippe G. Nantermet
- Current Assignee Address: US NJ Rahway; US PA Collegeville; US PA North Wales; US PA West Point; US NJ Westfield; US NJ Bridgewater; US NJ Edison; US CA San Carlos; US NJ Princeton Junction; US NJ Fanwood; US NJ Westfield; US PA Furlong; US NJ Summit; US PA Harleysville; US PA Philadelphia; US PA North Wales
- Agent Sylvia A. Ayler; Catherine D. Fitch
- International Application: PCT/US2017/061221 WO 20171113
- International Announcement: WO2018/093694 WO 20180524
- Main IPC: C07D417/12
- IPC: C07D417/12 ; C07D417/14 ; C07D277/52 ; C07D471/04 ; C07D487/10 ; C07D401/12 ; C07D471/08 ; C07D471/10 ; C07D487/04 ; C07D487/08

Abstract:
Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1A to R4A are defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same.
Information query