Invention Grant
- Patent Title: Antidiabetic spirochroman compounds
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Application No.: US16465156Application Date: 2017-12-15
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Publication No.: US10968232B2Publication Date: 2021-04-06
- Inventor: Michael Miller , Harry R. Chobanian , Shuwen He , Jinsong Hao , Barbara Pio , Yan Guo , Dong Xiao
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- International Application: PCT/US2017/066568 WO 20171215
- International Announcement: WO2018/118670 WO 20180628
- Main IPC: C07D491/107
- IPC: C07D491/107 ; A61P3/10 ; C07D311/96 ; C07D405/12

Abstract:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Public/Granted literature
- US20190337961A1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS Public/Granted day:2019-11-07
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