Invention Grant
- Patent Title: Trimer stabilizing HIV envelope protein mutations
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Application No.: US16039860Application Date: 2018-07-19
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Publication No.: US10968254B2Publication Date: 2021-04-06
- Inventor: Johannes Petrus Maria Langedijk , Lucy Rutten , Nika Mindy Strokappe , Daphné Truan
- Applicant: Janssen Vaccines & Prevention B.V.
- Applicant Address: NL Leiden
- Assignee: Janssen Vaccines & Prevention B.V.
- Current Assignee: Janssen Vaccines & Prevention B.V.
- Current Assignee Address: NL Leiden
- Agency: Ice Miller LLP
- Priority: EP17182075 20170719,EP17191083 20170914,EP18158862 20180227,EP18178358 20180618
- Main IPC: C07K14/005
- IPC: C07K14/005 ; A61K39/12 ; A61P31/18 ; A61K39/00
Abstract:
Human immunodeficiency virus (HIV) envelope proteins having specified mutations that stabilize the trimeric form of the envelope protein are provided. The HIV envelope proteins described herein have an improved percentage of trimer formation and/or an improved trimer yield. Also provided are particles displaying the HIV envelope proteins, nucleic acid molecules and vectors encoding the HIV envelope proteins, as well as compositions containing the HIV envelope proteins, particles, nucleic acid, or vectors.
Public/Granted literature
- US20190023744A1 TRIMER STABILIZING HIV ENVELOPE PROTEIN MUTATIONS Public/Granted day:2019-01-24
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