- Patent Title: Methods for treating multiple myeloma and the use of companion biomarkers for 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile
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Application No.: US16420031Application Date: 2019-05-22
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Publication No.: US10969381B2Publication Date: 2021-04-06
- Inventor: Joshua Hansen , Courtney G. Havens , Antonia Lopez-Girona , Gang Lu , Lilly L. Wong
- Applicant: Celgene Corporation
- Applicant Address: US NJ Summit
- Assignee: Celgene Corporation
- Current Assignee: Celgene Corporation
- Current Assignee Address: US NJ Summit
- Agency: Jones Day
- Main IPC: G01N33/50
- IPC: G01N33/50 ; G01N33/68 ; G01N33/574 ; A61K31/496 ; A61K45/06 ; A61P35/00
Abstract:
A method of identifying a subject having cancer who is likely to be responsive to a treatment compound, comprising administering the treatment compound to the subject having the cancer; obtaining a sample from the subject; determining the level of a biomarker in the sample from the subject; and diagnosing the subject as being likely to be responsive to the treatment compound if the level of the biomarker in the sample of the subject changes as compared to a reference level of the biomarker; wherein the treatment compound is Compound 1, Compound 2, or Compound 3.
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