Invention Grant
- Patent Title: Method to monitor and quantify interphase nuclear envelope rupture events
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Application No.: US16077744Application Date: 2017-02-17
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Publication No.: US10969389B2Publication Date: 2021-04-06
- Inventor: Matthieu Piel , Matteo Gentili , Matthew Raab , Nicolas Manel
- Applicant: INSTITUT CURIE , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Applicant Address: FR Paris; FR Paris; FR Paris
- Assignee: INSTITUT CURIE,INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE),CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee: INSTITUT CURIE,INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE),CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee Address: FR Paris; FR Paris; FR Paris
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: EP16305184 20160218
- International Application: PCT/EP2017/053665 WO 20170217
- International Announcement: WO2017/140875 WO 20170824
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/569 ; G01N33/50 ; A01K67/027
Abstract:
The present invention provides an in vitro method for monitoring interphase nuclear envelope rupture events in a eukaryotic cell or screening or identifying compound capable of increasing or decreasing the intensity and/or frequency of interphase nuclear envelope rupture events in a eukaryotic cell. These methods relate on a protein having a cytosolic non-nuclear localization in interphase and a non-sequence specific DNA binding activity. Interphase nuclear envelope rupture events are characterized by the presence of the protein of the invention in the nucleus of the eukaryotic cell.
Public/Granted literature
- US20190033311A1 METHOD TO MONITOR AND QUANTIFY INTERPHASE NUCLEAR ENVELOPE RUPTURE EVENTS Public/Granted day:2019-01-31
Information query
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