Invention Grant
- Patent Title: Complexes between anti-TNF antibodies, trimeric TNF proteins and organic molecules binding them
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Application No.: US15736535Application Date: 2015-10-22
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Publication No.: US10969393B2Publication Date: 2021-04-06
- Inventor: James Philip O'Connell , John Robert Porter , Alastair Lawson , Daniel John Lightwood , Rebecca Jayne Munro
- Applicant: UCB Biopharma SRL
- Applicant Address: BE Brussels
- Assignee: UCB Biopharma SRL
- Current Assignee: UCB Biopharma SRL
- Current Assignee Address: BE Brussels
- Agency: Medler Ferro Woodhouse & Mills PLLC
- Priority: GB1510758 20150618
- International Application: PCT/EP2015/074527 WO 20151022
- International Announcement: WO2016/202414 WO 20161222
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07K14/525 ; C07D471/00 ; C07K14/705 ; C07K16/24 ; C07D213/72 ; C07D235/04 ; C07D239/26 ; C07D471/04 ; A61K47/64 ; A61P37/00 ; A61P35/00 ; G01N33/68
Abstract:
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
Public/Granted literature
- US10935553B2 Complexes between anti-TNF antibodies, trimeric TNF proteins and organic molecules binding them Public/Granted day:2021-03-02
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