The present disclosure provides a method, an apparatus and a device for detecting a fatigue state. In this method, by receiving an initial image sent by a 3D sensor, where the initial image includes depth information containing an eye contour, extracting eye state information from the initial image, and determining whether a user is currently in the fatigue state according to the eye state information, detecting whether the user is in the fatigue state through the eye state information is thereby achieved, with high detection efficiency and more accurate detection results.