A system and method for differentially locating and modifying audio sources that includes receiving multiple audio inputs from a set of distinct locations; determining a multi-dimensional audio map from the audio inputs; acquiring a set of positional audio control inputs applied to the audio map, each audio control input comprising a location and audio processing property; and generating an audio output according to the audio control inputs and the audio inputs. The audio control inputs capable of configuration through manual, automatic, computer vision analysis, and other configuration modes.