Methods and systems for disabling barcode reader illumination and aiming operation based on barcode reader position are disclosed herein. An example method includes a barcode reader determining its angular position, for example, from an accelerometer mounted in the barcode reader. That angular position is compared against a reference angular position and a determination is made whether barcode reader is in a disable angular region. When in the disable angular region, the barcode reader automatically disables illumination and/or aiming operation until the angular position enters an enable angular region. That enable angular region may be different than the disable angular region, and both may be adjustable.