Systems and methods for loss protection of audio streams that may obtain an audio source such as from a microphone device, determine a sampling rate for encoding the audio source, and sampling the audio source to identify a plurality of samples (e.g., according to the sampling rate). A first audio output stream may be generated by encoding the plurality of samples. A second audio output stream may be generated by compressing each sample of the plurality of samples to collectively generate a second audio output stream. The first and second audio output streams may be transmitted (e.g., over a network subject to loss) to a recipient computer system that is able to utilize portions of the second audio output stream in place of lost portions first audio output stream.