An OLED display panel and manufacturing method are provided. Through disposing a light-shielding film on the packaging cover plate to prevent the laser from illuminating on the electrodes of the MED substrate during the laser scanning of the sealant to effectively protect the electrode. A portion of the light shielding film that overlaps with the thin layer region of the sealant has gradually decreasing light transmittance, which can prevent the problem that the thin layer region of the sealant is scorched by excessive laser energy, sufficiently ensures that the packaging effect, and reduces the generation of particles. In addition, the surface of the light-shielding film irradiated with laser light is a frosted surface, which can cause diffused reflection of the laser light irradiated on the light-shielding film to prevent the laser from directly reflecting on the laser head and protect the laser head from being burned and damaged.