Disclosed are methods, systems, devices, apparatus, media, design structures, and other implementations, including a method that includes receiving a signal for radio transmission, and configuring crest factor reduction (CFR) processing characteristics, at a wireless device, to apply to the received signal to modify one or more portions of the signal based on an asymmetrical spectral mask, representative of an asymmetric frequency envelope limiting allowed magnitudes for frequency components bounded by the asymmetrical spectral mask, with the asymmetrical spectral mask being defined based on spectral characteristics requirements specified by multiple regulatory radio frequency (RF) power requirements at frequencies affecting a frequency range of the asymmetrical spectral mask. The method further includes applying CFR processing to the received signal according to the configured CFR processing characteristics to produce a resultant output signal with a resultant spectral representation bound by the asymmetrical spectral mask.